ea0049ep638 | Growth hormone IGF axis - basic | ECE2017
Wolf Peter
, Smajis Sabina
, Gajdosiik Martin
, Pfleger Lorenz
, Winhofer Yvonne
, Anderwald Christian-Heinz
, Trattnig Siegfried
, Luger Anton
, Krssak Martin
, Krebs Michael
Background: Altered hepatic mitochondrial activity plays a key role in the development of non-alcoholic fatty liver disease (NAFLD). GH has been shown to stimulate mitochondrial function in skeletal muscle. Therefore we hypothesize that the time course of serum GH concentrations during an oral glucose tolerance test might be related to hepatic mitochondrial energy metabolism in vivo in humans.Methods: 15 volunteers (male/female: 7/8; 55±8 y...